Welcome to tRFUniverse!

tRFUniverse is a novel comprehensive web app for the interactive analysis of tRNA-derived ncRNAs in human cancer. tRFUniverse presents the most extensive collection of different classes of tRNA-derived ncRNAs analyzed across all the TCGA tumor cohorts (~11,000 samples), NCI-60 cell lines, several different human biological fluids (~293 samples), and across all the pediatric tumor cohorts available on TARGET (~2,000 samples). Moreover, several AGO CLASH/CLEAR/CLIP-Seq data (82 samples) were analyzed to identify the molecular interactions between tRNA-derived ncRNAs and other transcripts.

tRFUniverse combines in a single resource a set of analytical features that may be helpful to researchers in investigating the involvement of these small RNA molecules in cancer biology. Relevant examples include (i) target enrichment analyses; (ii) phenotype simulation analysis; (iii) correlation analyses; (iv) metadata-mediated correlation analyses; (v) correlated genes enrichment analyses; (vi) survival analysis; (vii) literature knowledge-graph analyses; (viii) dimensionality reduction analyses; (ix) cluster analyses; (x) differential expression analyses; and (xi) differential survival analyses.